Fast, powerful multi-symptom relief for your headache, fever, sore throat, minor aches and pains, sneezing, runny nose, and cough: Nyquil Cold and Flu liquid medicine temporarily relieves common cold and flu symptoms so you can get the rest you need.. Nyquil Cold and Flu contains 10% alcohol but its active ingredients are acetaminophen for pain relief and fever reduction; dextromethorphan to suppress coughs; and doxylamine succinate to help you sleep – because, more often than not, rest is the best healer.. Bottle contains 12 ounces of cold and flu symptom reliever..